Harry Smilkstein (1911–1994) was an American illustrator and cartoonist who worked across comic books, magazine illustration and newspaper features.

Born in Stamford, Connecticut, he began working professionally during the 1930s, when comics and pulp magazines offered expanding markets for artists. His early credits include work associated with The Lone Ranger and comic-book publisher Centaur. Smilkstein later contributed illustrations to newspapers and magazines, including work documented in the New York Daily News.